Final Year B.

Pharm (Sem VII) R 2019 syllabus

Novel Drug Delivery System (BP704T)

Unit Details Details to be covered Hours Reference books

allotted
I Definition and difference 10
between CR & SR,
Controlled drug delivery rationale, advantages &
systems: Introduction, disadvantages of CR,
terminology/definitions and selection of drug candidates.
rationale, advantages, Approaches to design-
disadvantages, selection of controlled release
drug candidates. Approaches formulations based on
to design-controlled release diffusion, dissolution and
formulations based on ion exchange principles. Robinson, J. R., Lee
diffusion, dissolution and ion Physicochemical and V. H. L, Controlled
exchange principles. biological properties of Drug Delivery
Physicochemical and drugs relevant to controlled Systems, Marcel
biological properties of drugs release formulations (7 Dekker, Inc., New
relevant to controlled release HRS.) York, 1992. Lachman
formulations Enlist the evaluation & Libermann,
parameters for CR systems. Controlled Drug
Polymers: Introduction, In vitro dissolution method Delivery Concepts &
classification, properties, Polymers: Introduction, Advances by Vyas
advantages and application of classification wrt CR, and Khar Second
polymers in formulation of properties in brief, Edition, Remington
controlled release drug advantages and applications Pharmaceutical
delivery systems. wrt CR (3 HRS.) science, Brahmankar
II Microencapsulation: 10
Definition, advantages and
Microencapsulation: disadvantages, different
Definition, advantages and types of microspheres
disadvantages, microspheres /microcapsules,
/microcapsules, microparticles in brief,
microparticles, methods of methods of
microencapsulation, microencapsulation:
applications multiorifice centrifugal
process, Wurster, Spray
Mucosal Drug Delivery Drying and Spray
system: Introduction, congealing, phase
Principles of bioadhesion / separation and coacervation
mucoadhesion, concepts, in brief, applications wrt
advantages and pharma. only enlist Lachman &
disadvantages, transmucosal evaluation parameters Libermann,
permeability and formulation (4HRS.) Controlled Drug
considerations of buccal Mucosal Drug Delivery Delivery Concepts &
delivery systems system: Introduction, Advances by Vyas
Principles of bioadhesion/ and Khar Second
Implantable Drug Delivery mucoadhesion, concepts, Edition, Theory and
Systems: Introduction, (only contact and Practice in Novel
advantages and consolidation stages), Enlist Drug Delivery System
disadvantages, concept of Theories of mucoadhesion, by S. P. Vyas,
implants and osmotic pump advantages and Robinson
 disadvantages, transmucosal
permeability and
formulation considerations
of buccal delivery systems.
Enlist evaluation tests
(4HRS.)

Implantable Drug Delivery

Systems: Introduction,
advantages and
disadvantages, concept of
implants, only Alzet
osmotic pump (2HRS.)
III Transdermal Drug Delivery 10
Systems: Introduction,
Permeation through skin
(different routes of
permeation in short), factors
affecting permeation,
permeation enhancers (only
chemical permeation
enhancers), basic
components of TDDS
(enlist all formulation
approaches and explain in
details Membrane
permeation controlled
systems), enlist the
evaluation parameters of
TDDS (4 HRS.)
Transdermal Drug Delivery
Systems: Introduction, Gastroretentive drug
Permeation through skin, delivery systems:
factors affecting permeation, Introduction, advantages,
permeation enhancers, basic disadvantages, approaches
components of TDDS, for GRDDS – Floating, high
formulation approaches density systems, inflatable
and gastroadhesive systems
Gastroretentive drug delivery and their applications.
systems: Introduction, Evaluation tests; only
advantages, disadvantages, floating time, and floating
approaches for GRDDS – lag time (4 HRS.)
Floating, high density systems,
inflatable and gastroadhesive Nasopulmonary drug
systems and their applications delivery system:
Introduction to Nasal and
Nasopulmonary drug delivery Pulmonary routes of drug Lachman &
system: Introduction to Nasal delivery, Formulation of Libermann,
and Pulmonary routes of drug Inhalers (dry powder and Controlled Drug
delivery, Formulation of metered dose) (working), Delivery Concepts &
Inhalers (dry powder and nasal sprays, nebulizers (as Advances by Vyas
metered dose), nasal sprays, accessories), enlist and Khar Second
nebulizers evaluation parameters and Edition,
 explain in brief only
Cascade Impactor (2 HRS.)
IV Targeted drug Delivery: 8
Concepts and approaches
advantages and
disadvantages, Introduction
to liposomes (mention
composition with
examples), niosomes
(mention composition with
examples), nanoparticles
(mention composition with Y W. Chien, Novel
examples), only one Drug Delivery
mechanical dispersion Systems, 2nd edition,
method of hand shaking or revised and expanded
solvent evaporation (alcohol Marcel Dekker, Inc.,
or ether) for liposomes and New York, 1992.
polymerization method for Controlled Drug
nanoparticles to be covered Delivery Concepts &
remaining can be enlisted. Advances by Vyas
Enlist evaluation and Khar Second
Targeted drug Delivery: parameters. Monoclonal Edition, Theory and
Concepts and approaches antibodies (Hybridoma Practice in Novel
advantages and technique of preparation), Drug Delivery System
disadvantages, introduction to applications by S. P. Vyas,
liposomes, niosomes, Targeted and
nanoparticles, monoclonal Controlled Drug
antibodies and their Delivery by Vyas &
applications . Khar
V Ocular Drug Delivery 7
Systems: Introduction, intra
ocular barriers and methods
to overcome (completed in
Sem V, can be revised) –
Preliminary study (factors
related to isotonicity, pH
and other formulation
aspects completed in Sem
V, can be revised),enlisting
all approaches for ocular
Ocular Drug Delivery formulations and explaining Controlled Drug
Systems: Introduction, intra e.g. insitu gels and ocuserts Delivery Concepts &
ocular barriers and methods (erodible and non erodible Advances by Vyas
to overcome –Preliminary inserts ) (5HRS.) and Khar Second
study, ocular formulations Intrauterine Drug Delivery Edition, Theory and
and ocuserts Systems: Introduction, Practice in Novel
advantages and Drug Delivery System
Intrauterine Drug Delivery disadvantages, types of by S. P. Vyas,
Systems: Introduction, IUD's like medicated and Targeted and
advantages and non medicated, enlist all Controlled Drug
disadvantages, types but explain any one Delivery by Vyas &
development of intra uterine design, development of intra Khar, Modern
devices (IUDs) and uterine devices (IUDs) and Pharmaceutics by
applications applications (2 HRS.) Banker
Question paper pattern for end semester theory examinations
for 75 marks paper
I. (Answer all the questions)
Multiple Choice Questions (MCQs) = 20 x 1 = 20
OR
Objective Type Questions =10 x 2 = 20
OR
Multiple Choice Questions (MCQs) = 10 x 1 = 10 and Objective Type Questions (5 x 2) = 10
II. Long Answers (Answer 2 out of 3) = 2 x 10 = 20
III. Short Answers (Answer 7 out of 9) = 7 x 5 = 35

Q1 2 Marks each
a b c d e f g h i j Total
1.1 1.2 2.1 2.2 2.3/5.2 3.1 3.2 3.3 4 5.1 20
Q2 10 marks each: (any 2 out of 3)
a b c
1.1 2.1/4 5.1 20
Q3 5 marks each: (any 7 out of 9)
a b c d e f g h i
1.1 1.2 2.1 2.2/3.3 2.3/5.2 3.1 3.2 4 5.1 35

TOTAL 75