Acute Respiratory Infection

ACUTE
RESPIRATORY
INFECTIONS
Pneumonia
Bronchiolitis
Dr. Dwi Wastoro, SpAK
Acute Respiratory Infections (ARI)

Developed and developing countries
High morbidity
5 8 episodes/year/child
30 50 % outpatient visit
10 30 % hospitalization
Developing countries
High mortality
30 70 times higher than in developed countries
1/4 - 1/3 death in children under five year of age
ARI-ASSOCIATED DEATH RATE BY AGE

TEKNAF, BANGLADESH, 1982-1985
Deaths per 1000 children
140
120
100
80
60
40
20
0
1-5
6-11
12-23
Age in M onths
24-35
36-50
Distribution of 12.2 million deaths among

children less than 5 years old in all developing
countries, 1993
ARI/Malaria (1.6%)
Malaria (6.2)
ARI (26.9%)
Other (33.1%)
Malnutrition
(29%)
ARI/Measles (5.2%)
Measles (2.4%)
Diarrhoea/measles
(1.9%)
Diarrhoea (22.8%)
RISK FACTORS FOR PNEUMONIA

OR DEATH FROM ARI
Malnutrition, poor
breast feeding
practices
Lack of immunization
Vitamin A deficiency
Young age
Low birth weight
Increase
risk of
ARI
Crowding
High prevalence
of nasopharyngeal
carriage of
pathogenic bacteria
Cold weather
or chilling
Exposure to air pollution
Tobacco smoke
Biomass smoke
Environmental air pollution
Magnitude of the Problem

in Indonesia
Pneumonia in children (< 5 years of age)
Morbidity Rate 10-20 %
Mortality Rate 6 / 1000
Pneumonias kill
50.000
/ a year
12.500 / a month
416 / a day = passengers of 1 jumbo jet plane
17 / an hour
1 / four minutes
Pneumonia is a no 1 killer for infants

(Balita)
Pneumonia
Classifications
Anatomical classification
Lobar pneumonia
Lobular pneumonia
Intertitial pneumonia
Bronchopneumonia
Etiological classification
Bacterial pneumonia
Viral pneumonia
Mycoplasma pneumonia
Aspiration pneumonia
Mycotic pneumonia
Etiology of Pneumonia
Predominantly : bacterial and viral

In developing countries:
bacterial > viral
(Shann,1986): In 7 developing countries,
bacterial 60 %
(Turner, 1987): In developed countries,
bacterial 19 % ; viral 39 %
Bacterial etiology
Streptococcus pneumoniae
Hemophilus influenzae
Staphylococcus aureus
Streptococcus group A B
Klebsiella pneumoniae
Pseudomonas aeruginosa
Chlamydia spp
Mycoplasma pneumoniae
BACTERIA ISOLATED FROM LUNG ASPIRATES

IN 370 UNTREATED CHILDREN WITH PNEUMONIA
%
50
40
30
20
10
0
S Pneumoniae
H Influenzae
S Aureus
Characteristic features
S pneumoniae
mucosal inflammation lesion
alveolar exudates
frequently lobar pneumonia)
H influenzae, S viridans, Virus
invasion and destruction of mucous membrane
Staphylococcus, Klebsiella
destruction of tissues multiple abscesses
Simple Clinical Signs of

Pneumonia (WHO)
Fast breathing (tachypnea)
Respiratory thresholds
Age
Breaths/minute
< 2 months
60
2 - 12 months
50
1 - 5 years
40
Chest Indrawing
(subcostal retraction)
Pathology and Pathogenesis

Bacteriae peripheral lung tissues
tissues reaction oedematous
Red Hepatization Stadium
alveoli consist of : leucocyte, fibrine,erythrocyte,
bacteria
Grey Hepatization Stadium
fibrine deposition, phagocytosis
Resolution Stadium
neutrophil degeneration, loose of fibrine,
bacterial phagocytosis
Bronchopneumonia
Early stages of acute bronchopneumonia. Abundant inflammatory
cells fill the alveolar spaces. The alveolar capillaries are distended
and engorged.
Bronchopneumonia
Acute bronchopneumonia. The alveolar spaces contain abundant
PMNs and an inflammatory infiltrate rich in fibrin.
Acute Bronchopneumonia
Acute bronchopneumonia; the alveolar spaces are full and distended
with PMNs and a proteinaceous exudate. Only the alveolar septa
allow identification of the tissue as lung.
Radiographic patterns
1. Diffuse alveolar and interstitial
pneumonia (perivascular and
interalveolar changes)
2. Bronchopneumonia
(inflammation of airways and
parenchyma)
3. Lobar pneumonia
(consolidation in a whole lobe)
4. Nodular, cavity or abscess lesions
(esp.in immunocompromised patients)
Blood Gas Analysis & Acid Base Balance

Hypoxemia (PaO2 < 80 mm Hg)
with O2 3 L/min 52,4 %
without O2 100 %
Ventilatory insufficiency
(PaCO2 < 35 mmHg)
87,5 %
Ventilatory failure
(PaCO2 > 45 mmHg )
4.8 %
Metabolic Acidosis
poor intake and/or hypoxemia

(Mardjanis Said, et al. 1980)
44,4 %
Management
Severe Pneumonia
Hospitalization
Antibiotic administration
Procain Pennicilline, Chloramphenicol
Amoxycillin + Clavulanic Acid
Intra Venous Fluid Drip

Oxygen
Detection and management of
complications
Complications
Pleural effusion (empyema)
Piopneumothorax
Pneumothorax
Pneumomediastinum
Bronchiolitis
Bronchioles
inflammation
Clinical
syndromes:
fast breathing, retractions, wheezing
Predominantly
< 2 years of age
(2 6 months)
Difficult
to differentiate with pneumonia
Bronchiolitis
Etiology
Predominantly RSV (Respiratory Syncytial
Virus), adenovirus etc.
Diagnosis
Etiological diagnosis
Microbiologic examination
Clinical diagnosis
Signs and symptoms

Age
Resource of infection
Bronchiolitis
Clinical Manifestations
cough, cold, fever,fast breathing, retraction,
wheezing, irritable, vomitus, poor intake
Physical Examinations
tachypnea, tachycardia, retraction,
expiration >, wheezing, fever,pharyngitis,
conjunctivitis, otitis media.
Bronchiolitis
Radiologic examination
diffuse hyperinflation
flat diaphragm,
subcostal >
retrosternal space >
peribronchial infiltrates
pleural effusion (rare)
Bronchiolitis
Management
Supportive
Severe disease
hospitalization
intra venous fluid drip
oxygen
(antibiotics)
Bronchodilator: controversial
Corticosteroid: controversial
Bronchiolitis
Natural history & complications
Improved clinical findings : in 3-4 days
Improved radiological features: in 9 days
Persistent respiratory obstruction : 20%

Respiratory failure : 25 %
Lung collaps (rare)
Bronchiolitis
Correlation with Asthma

30 % - 50 % becomes asthmatic patients
Similarity in :
- pathogenic
mechanisms
- pathologic
disorders

Acute Respiratory Infection

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ACUTE

Acute Respiratory Infections (ARI)

ARI-ASSOCIATED DEATH RATE BY AGE

Distribution of 12.2 million deaths among

RISK FACTORS FOR PNEUMONIA

Low birth weight

Magnitude of the Problem

Pneumonia is a no 1 killer for infants

Predominantly : bacterial and viral

BACTERIA ISOLATED FROM LUNG ASPIRATES

H influenzae, S viridans, Virus

invasion and destruction of mucous membrane

destruction of tissues multiple abscesses

Simple Clinical Signs of

Pathology and Pathogenesis

Blood Gas Analysis & Acid Base Balance

(PaCO2 < 35 mmHg)

(PaCO2 > 45 mmHg )

poor intake and/or hypoxemia

Intra Venous Fluid Drip

< 2 years of age

to differentiate with pneumonia

Signs and symptoms

Persistent respiratory obstruction : 20%

Correlation with Asthma

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