Contraception: David Blair Toub, M.D. Dept. of Obstetrics and Gynecology Pennsylvania Hospital
Contraception: David Blair Toub, M.D. Dept. of Obstetrics and Gynecology Pennsylvania Hospital
Contraception: David Blair Toub, M.D. Dept. of Obstetrics and Gynecology Pennsylvania Hospital
4
3
3
2
2
0.8
1 0.5
0.3 0.2
0.1 0.04
0
Spermicides Comb. Prog. OCP's Diaphragm Condom Depo- Cu-T380A Norplant TL
OCP's Provera
Hormonal Contraception:
Combination OCPs
Contain Synthetic Estrogen/Progestin
Modern E2 Dosage 50 Mcg
Despite Diversity, Side Effects and
Efficacies Similar
Requires Patient Compliance
May Be Monophasic or Triphasic
Combination OCPs:
Mechanism of Action
Suppresses LH / FSH Release
(E2 FSH, P LH)
Progestin Thickens Cervical Mucus and
Alters Endometrium
Major Effect Is Anovulation and
Impairment of Sperm Transport and
Ocyte Implantation
Combination OCPs:
Additional Benefits
Menstrual Regulation
Decreased Risk of Anemia
Ovarian, Endometrial CA: Risk
Lower PID Risk
Prevention of Benign Breast Disease
Combination OCPs:
Side Effects
Breakthrough Bleeding ( 25%)
Amenorrhea
Breast Tenderness, Nausea
H/A (+/)
?HTN
?Weight Gain
Combination OCPs:
Risks
Thromboembolism ( 35 yo, Smoker)
MI (Smokers Only):
< 15 cig/day: 3X Risk
> 15 cig/day : 21X Risk
Liver Adenomas (Very Rare)
Depo-Provera:
Inhibits Ovulation
150 mg q3months (14 day grace period)
Delayed Ovulation After Discontinuation
Main Side-Effects:
Amenorrhea
AUB
Weight Gain
Hair Loss
Norplant:
Implantable for 5 Years
Similar Side Effects as Depo-Provera
Avg. Yearly Failure Rate: 0.8/100
(Increases : > 2/100 after 5 years)
Occasionally Difficult to Remove
Barrier Methods:
Diaphragm: High Failure Rates
Must Remain in ~6 Hrs post-coitus
Best if Combined with Spermicide
UTI Potential
Condom: STD Protection, Inconsistent Use by
Men
Female Condom: Cumbersome, Learning Curve
Today Sponge: As seen on Seinfeld
IUD: Overview
ParaGard (CuT380A), Progestasert
Very Effective (~ TL), Reversable
Risks OVERBLOWN
Monogamy Essential, However
Does Not Protect Against STDs
Can Remain for 10 Years
IUD:
Mechanisms of Action
NOT ABORTIFACIENT!!!!!!!!
Prevents Conception:
TCN Probably OK
Most Anticonvulsants Impair Efficacy
of Hormonal Contraceptives