0% found this document useful (0 votes)
6 views

Cell II

Uploaded by

shrestharohan007
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
0% found this document useful (0 votes)
6 views

Cell II

Uploaded by

shrestharohan007
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
You are on page 1/ 17

Intercellular Junction and

Communication

Dr. Shiva Upadhaya


MBBS, MD
Clinical Physiology
Objectives:

• To describe about intercellular junctions and


communication.
Intercellular Junctions
• Junction formed between the cell are called
intercellular junction.
• Types:
A) junctions that tie cells together.
1) Tight junctions.
2) Anchoring junctions.
a) Cell to cell anchoring junction.
-Desmosome.
-Zonula adherens.
Intercellular Junctions
b) Cell to basal lamina anchoring junctions.
-Hemidesmosome.
-Focal adhesion.
B)Junctions that allow transfer of ions and small
molecules:
1) Gap junctions.
Tight Junctions
• Tight junctions are commonly found in
epithelium of GI tract, nephrons, urinary tract,
hepatobiliary tract and choroid plexus.
• Located towards apical
region of cells.
Tight Junctions
• At tight junctions, outer layer of cell membrane of
neighboring cells fuse with each other that
obliterates the intercellular space close to their
apical margin.
• They form the barrier for transport of solute and
solvent from lumen into interstitial space and
between cells.
• Membrane proteins that contribute to formation of
tight junction belong to three families: occludin,
claudins and junctional adhesion molecules.
Desmosomes
• They are the junctions characterized by focal
thickening of two adjacent cell membrane.
• Thickened area is presence of dense layer of
proteins on the cytoplasmic surface of
membrane.
Zonula Adherens
• Located below the base of tight junctions.
• Major site of attachment for intracellular
microfilaments.
• Cadherins are present in intercellular junction.
Hemidesmosomes
• Look like half of desmosomes.
• Microfilaments are attached to it
intracellularly.
• Laminar-cellular space between two
membrane containing filamentous cell
adhesion called as integrins.
Focal Adhesions
• It connect cell to basal lamina.
• Intracellularly, they are associated with actin
filaments so they assist in cell movements.
Gap Junction
• It is made up of special transmembrane
protein-connexons.
Gap Junctions
• Gap junctions are clusters of intercellular channels that allow
direct diffusion of ions and small molecules between adjacent
cells.
• At gap junctions, the intercellular space narrows from 25 nm
to 3 nm.
• The functional unit of the gap junction is the connexon.
• A connexon is composed of six integral membrane protein
subunits called connexins.
• Gap junctions were first discovered in myocardium and nerve
because of their properties of electrical transmission between
adjacent cells (Weidmann 1952; Furshpan and Potter 1957).
Gap Junctions
• Functions:
-Electrical synapses.
-Permit passage of organic solute such as
sugar and aminoacids.
-Chemical messengers and hormones are also
exchanged between cell through gap junction.
Intercellular communications
• Intercellular communication refers to the transfer of
information from one cell to another.
• It is also called cell signaling .
• The cells of the body communicate with each other
through some chemical substances called chemical
messengers.
• The cell which releases signaling molecules is called the
signaling cell.
• The cell which responds to the signaling molecules is called
the target cell.
Intercellular Communication
Thank You

You might also like

pFad - Phonifier reborn

Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy