David Watt, PhD
About
Faculty Rank
- Professor
Training & Education
Fellowship
NIH Postdoctoral Fellow, Biochemistry, Harvard University, Cambridge, MA, 1972-73, with Professor Konrad Bloch
Degree
Ph.D., Harvard University, Cambridge, MA, 1972, with Professor E. J. Corey
A.M., Harvard University, Cambridge, MA, 1969
A.B., Dartmouth College, Hanover, NH, 1967
Research
Research Focus
Development of small-molecule activators and inhibitors relevant to cancer, infectious disease and epilepsy.
Programs
Translational OncologyCollege & Department
Contact Information
421 Bio-Pharm Building
University of Kentucky
Lexington, KY 40536
United States
Phone
Email
Publications
- Phenylethynyl-substituted Heterocycles Inhibit Cyclin D1 and Induce the Expression of Cyclin-dependent Kinase Inhibitor p21Wif1/Cip1 in Colorectal Cancer CellsSviripa, VM; Kril, LM; Zhang, W; Xie, Y; Wyrebek P; Ponomareva, L; Liu, X; Yuan, Y; Zhang, C-G; Watt, DS; Liu, C (2018) MedChemComm, 9(1):87-99.
View Publication - Inhibition of Dihydrotestosterone Synthesis in Prostate Cancer by Combined Frontdoor and Backdoor Pathway BlockadeFiandalo, MV;. Stocking, JS; Pop, EA; Wilton, JH; Mantione, KM; Li, Y; Attwood, KM; Azabdaftari, G; Wu, Y; Watt, DS; Wilson, EM; Mohler, JL (2018) Oncotarget, 9(13):11227-11242.
View Publication - Mathematical Modeling of Intracrine Androgen Metabolism in Prostate Cancer: Methodological AspectsCook, SF; Fiandalo, MV; Watt, DS: Wu, Y; Mohler, JL; Bies, RR (2018) Prostate, Jun 25 DOI: 10.1002/pros. 23665.
- Efficient Synthesis of Aurone Mannich Bases and Evaluation of their Antineoplastic Activity in PC-3 Prostate Cancer CellsPopova, AV; Frasinyuk, MS; Bondarenko, SP; Zhang, W; Xie, Y; Martin, ZM; Cai, X; Fiandalo, MV; Mohler, JL; Liu, C; Watt, DS; Sviripa, VM (2018) Chemical Papers, 72(10): 2443-2456.
- A Direct Synthesis of 2-(-Carboxyalkyl)isoflavones from ortho-Hydroxylated DeoxybenzoinsMrug, GP; Demydchyk, BA; Bondarenko, SP; Sviripa, VM: Wyrebek, P;. Mohler, JL; Fiandalo, MV; Liu, C; Frasinyuk, MS; Watt, DS (2018) Eur J Org Chem, 39: 5460-5463.
- N,N'-Diaryl-Bishydrazones in a Biphenyl Platform: Broad Spectrum Antifungal AgentsChandrika, NT; Dennis, EK; Shrestha, SK; Ngo, HX; Green, KD; Kwiatkowski, S; Deaciuc, AG; Dwoskin, LP; Watt, DS; Garneau-Tsodikova, S. (2019) Eur J Med Chem, 164: 273-281.
- Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafishXie, Y; Kril, LM; Yu, T; Zhang, W; Frasinyuk, MS; Bondarenko, SP; Kondratyuk, KM; Hausman, E; Martin, ZM; Wyrebek, PP; Liu, X; Deaciuc, A; Dwoskin, LP; Chen, J; Zhu, H; Zhan, C-G; Sviripa, VM; Blackburn, J; Watt, DS; Liu, C. (2019) Sci Reports, in press.
- Autophagic Flux Modulation by Wnt/β-catenin Pathway in Hepatocellular CarcinomaTurcios, L; Chacon, E; Garcia, C; Eman, P; Jiang, J; Spear, B; Liu, C; Watt, DS; Marti, F; Gedaly, R (2019) PLoS One 2019 Feb 22;14(2):e0212538. doi: 10.1371/journal.pone.0212538. eCollection 2019. PMID: 30794613.
- Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression.Zhang W, Sviripa V, Kril LM, Chen X, Yu T, Shi J, Rychahou P, Evers BM, Watt DS and Liu C. J Med Chem 54(5):1288-97, 2011.
- Quantification of trans-2,6-difluoro-4‘-dimethylaminostilbene in rat plasma: Application to a pharmacokinetic study.Lin HS, Sviripa VM, Watt DS, Liu C, Ong PS, and Ho PC. J Pharm Biomed Anal 72,115-120, 2012.
- Fluorinated N,N’-diarylureas as AMPK activators.Sviripa V, Zhang W, Conroy MD, Schmidt ES, Liu AX, Truong J, Liu C, Watt DS. Bioorg Med Chem Lett 23(6):1600-1603, 2013.
- Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A.Zhang W, Sviripa V, Chen X, Shi J, Yu T, Ward N, Kril L, Vander Kooi C, Evers M, Watt D, Liu C. ACS Chem Biol 8(4):796-803, 2013.