Journal of Natural Product Research and Applications
Thymelaea microphylla is an edible and medicinal species that exhibits high antioxidant activity ... more Thymelaea microphylla is an edible and medicinal species that exhibits high antioxidant activity and phenolic content. Moreover, four fractions (hexane, dichloromethane, methanol and water) were tested towards their ex-vivo antioxidant, anticancer, anti-inflammatory and antiviral effects. Dichloromethane fraction had marked protection against cell oxidative stress (IC50 = 1.5 µg/mL). Hexane, Dichloromethane and Methanol fractions exhibited prominent anti-proliferative activities against cancer cells especially A-549 cells, with very low IC50 values of 0.13, 0.018 and 0.5 µg/mL, respectively (50, 101 and 14 higher than Etoposide). Moreover, the three fractions showed no cytotoxicity on normal fibroblast WS-1. DCM exhibited high anti-inflammatory activity in RAW 264.7 cells. Theses fractions were also tested on herpes (HSV-1). MeOH fraction was the most active acting both directly on the virus and on its adsorption. Phenolics, terpenoids and saponins were the major classes. These find...
Six medicinal halophytes widely represented in North Africa and commonly used in traditional medi... more Six medicinal halophytes widely represented in North Africa and commonly used in traditional medicine were screened for pharmacological properties to set out new promising sources of natural ingredients for cosmetic or nutraceutical applications. Thus, Citrullus colocynthis, Cleome arabica, Daemia cordata, Haloxylon articulatum, Pituranthos scoparius and Scorzonera undulata were examined for their in vitro antioxidant (DPPH scavenging and superoxide anion-scavenging, β-carotene bleaching inhibition and iron-reducing tests), antibacterial (microdilution method, against four human pathogenic bacteria) and anti-tyrosinase activities. Besides, their aromatic composition was determined by RP-HPLC. H. articulatum shoot extracts exhibited the strongest antioxidant activity and inhibited efficiently the growth of Salmonella enterica and Escherichia coli. P. scoparius and C. arabica inhibited slightly monophenolase, whereas H. articulatum was the most efficient inhibitor of diphenolase activ...
Polyphenols are bioactive molecules exhibiting a lot of scientific attention due to their multipl... more Polyphenols are bioactive molecules exhibiting a lot of scientific attention due to their multiple biological activities. This study compared phenolic contents and antioxidant activity in Cynara cardunculus L. organs and focus on leaf phenolic compounds identification by RP-HPLC and their antibacterial activity. The analyzed organs exhibited different total polyphenol contents (7– 14.8 mg GAE g −1 DW). Leaf and seed phenolic contents were similar and two times higher than those in flowers. The same tendency was observed for the amount of flavonoids and tannins. However, seed extracts displayed the highest DPPH · scavenging ability with the lowest IC50 value (23 µg ml −1 ), followed by leaves and flowers (over 50 µg ml −1 ). In contrast, leaves showed the highest capacity to quench superoxide (IC50 :1µ g ml −1 ) as compared to seeds (6 µg ml −1 ). In addition, cardoon leaves were efficient to inhibit growth of pathogenic bacteria mainly against Staphylococcus aureus and Escherichia c...
Salinity and potassium deficiency are major abiotic constraints affecting plant growth, productiv... more Salinity and potassium deficiency are major abiotic constraints affecting plant growth, productivity, and metabolism. The present work was conducted to check whether salinity alleviates, aggravates, or does not affect the effects of potassium deficiency on Sulla carnosa , a salt-tolerant legume common in diverse saline soils. We investigated the changes in plant growth, phenolic compound composition, and antioxidant activity in stems and roots of this species grown hydroponically under different conditions: C, control (complete nutrient solution containing 6 mM K + and not added with NaCl); KD, K + deficiency (K + -deficient nutrient solution (60 μM K + ) not added with NaCl); C + S, salt treatment (control nutrient solution containing 6 mM K + and added with 100 mM NaCl); and KD + S, combined treatment between salinity and K + deficiency (K + -deficient nutrient solution (60 μM K + ) added with 100 mM NaCl). Results showed that all treatments applied led to a significant decrease of root and stem growth, with a more marked reduction in plants exposed to the combined stresses, suggesting synergistic effects of salinity and K + deficiency. In addition, results indicated that both stresses either applied alone or in combination quantitatively or qualitatively modulated phenolic compound accumulation and their antioxidant activities. But a predominance of K + deficiency effect was noticed, which may be considered as a suitable manipulation for the production of antioxidants compared to the other treatments.
This work focuses on the variability of Retama raetam (Forssk.) Webb bioactive compounds as a fun... more This work focuses on the variability of Retama raetam (Forssk.) Webb bioactive compounds as a function of the plant cycle. The main results showed that it exhibited the highest percentage of polyunsaturated fatty acids, along with superior levels of vitamin C and total phenolic compounds (66.49%, 645.6 mg·100 g−1 FW and 23.9 mg GAE·g−1, respectively) at the vegetative stage. Instead, at the flowering and mature fruiting stages, R. raetam (Forssk.) Webb exhibited notable contents of proline (25.4 μmol·g−1 DW) and carotenoids (27.2 μg·g−1 FW), respectively. The gathered data concerning the antioxidant activity highlighted the effectiveness of the vegetative stage in comparison to the other periods. Actually, IC50 and EC50 values of the hydromethanolic extract obtained from the plant shoots at the vegetative stage were of 23, 380, 410, 1160 and 960 μg·mL−1 (DPPH• and ABTS•+ radicals scavenging activity, reducing power, chelating power and β-carotene bleaching activity, respectively). F...
Total phenol content and the antioxidant activities of three cultivars of Opuntia ficus-indica (L... more Total phenol content and the antioxidant activities of three cultivars of Opuntia ficus-indica (L.) Mill. were evaluated. The results show that the ecotypes were significantly different according to their fatty acid composition, antioxidant and antibacterial activity, as well as their polyphenol profiles. Rossa fruit collected in August exhibited the higher phenolic content (15.48 mg GAE g −1 DW) with a stronger antioxidant activity. Bianca fruit collected in August exhibited a lower phenolic content (3.13 mg GAE g −1 DW) together with the stronger antiradical activity (96.14%). The advantage of this ecotype was more discernible as compared to positive controls butylated hydroxytoluene (BHT, 79.75%). Likewise, CpG chromatogram identification revealed also an important difference between the ecotypes on oleic and linoleic acids.
Antioxidants are the chemical substances that reduce or prevent oxidation. The present study aime... more Antioxidants are the chemical substances that reduce or prevent oxidation. The present study aimed to assess in vitro and ex vivo antioxidant activities of four acetonic extracts Tunisian halophytes (Suaeda fruticosa, Suaeda pruinosa, Suaeda mollis and Suaeda maritima). Various experimental models were used for characterization of antioxidant activities of shoot extracts. Eventually, the promising specie was subjected to phenolic identification using RP-HPLC. The analyzed shoot extracts exhibited that antioxidant activities varied considerably as function of species. The highest DPPH • scavenging ability was found in S. mollis with the lowest IC 50 value (2.5 g/ml), followed by S. pruinosa, S. fruticosa and S. maritima. The same tendency was observed with ferric reducing power. Concerning -carotene bleaching assays and total antioxidant activity, results showed that S. fruticosa exhibited the highest antioxidant ability against the inhibition of -carotene bleaching, and a better total antioxidant capacity. Moreover antioxidant capacities using ORAC method and a cell based-assay showed that S. mollis, S. fruticosa, and S. pruinosa exhibit statistically similar antioxidant activity. The identification of phenolic compounds in S. mollis extract using RP-HPLC revealed that 2,5-dihydroxybenzoic acid and rutin hydrate were the major molecules. These results suggested that Suaeda species showed a variability of their antioxidant activities.
Depuis la nuit des temps, les plantes ont été la source principale de molécules bioactives, tels ... more Depuis la nuit des temps, les plantes ont été la source principale de molécules bioactives, tels les composés phénoliques, capables de remédier à diverses maladies. Cependant, le contenu et l’activité des polyphénols dépendent d’un certain nombre de facteurs intrinsèques et extrinsèques. Dans le but d’optimiser les procédés d’obtention des principes actifs de la verveine (Verbena officinalis), les effets de la provenance de la plante, du solvant et de la méthode d’extraction ont été évalués. Ainsi, la partie aérienne de V. officinalis a été collectée dans deux régions différentes de la Tunisie (Bizerte et Ain Draham). L’extraction a été réalisée par macération, décoction et par l’appareil de Soxhlet tantôt avec de l’eau tantôt avec de l’éthanol pur. Une variabilité significative des teneurs en composés phénoliques ainsi que des capacités antioxydantes et antimicrobiennes des extraits a été observée en fonction des facteurs étudiés. De manière générale, les extraits éthanoliques sont...
Introduction. Essential oils and their components are currently of great interest as a potential ... more Introduction. Essential oils and their components are currently of great interest as a potential source of highly bioactive natural molecules. They are being studied for their possible use as safe alternative for food protection against oxidation and microbial spoilage. Objective. This study aimed on the phytochemical prospection of Thymus capitatus and Rosmainus officinalis essential oils and their oral toxicity evaluation. Material and methods. Chemical analysis of tested essential oils was carried out using gas chromatography combined to mass spectroscopic (GC-MS). Their safety limit was evaluated by acute toxicity. The antioxidant activity was estimated using in vitro methods. The antimicrobial activity was evaluated against twelve pathogenic germs. Results. Results showed that carvacrol and 1,8-cineol were the major compounds of Thymus capitatus and Rosmarinus officinalis essential oils. Acute toxicity results exhibited that both tested essential oils were inoffensive at 2000 m...
Mesembryanthemum edule is used as a food ingredient and in traditional medicine. In this study, w... more Mesembryanthemum edule is used as a food ingredient and in traditional medicine. In this study, we investigated antioxidant activities of several extracts (methanol/acidified water, v/v: 20/80; 40/60 and 60/40) obtained from M. edule leaf, stem and root. Then, individual phenolics were characterised by reversephase HPLC coupled to electrospray ionisation mass spectrometry and multi-stage MS fragment analysis. Results showed that 40% methanol leaf extract, 40% methanol root extract and 20% methanol stem extract displayed the highest scavenging activity against DPPH and ABTS radicals. Regarding LC/ESI-MS/MS identification of active phenols, there were significant differences among the fractions of interest. In fact, 40% leaf extract mainly contained procyanidins, whereas propelargonidins were the major phenolics in 20% methanol stem extract, while, in 40% root extract, the active compounds remained unidentified. These results indicate that edible M. edule can be used as a nutraceutical in the pharmaceutical industry.
Salinity and potassium deficiency are major abiotic constraints affecting plant growth, productiv... more Salinity and potassium deficiency are major abiotic constraints affecting plant growth, productivity, and metabolism. The present work was conducted to check whether salinity alleviates, aggravates, or does not affect the effects of potassium deficiency on Sulla carnosa, a salt-tolerant legume common in diverse saline soils. We investigated the changes in plant growth, phenolic compound composition, and antioxidant activity in stems and roots of this species grown hydroponically under different conditions: C, control (complete nutrient solution containing 6 mM K + and not added with NaCl); KD, K + deficiency (K +-deficient nutrient solution (60 μM K +) not added with NaCl); C + S, salt treatment (control nutrient solution containing 6 mM K + and added with 100 mM NaCl); and KD + S, combined treatment between salinity and K + deficiency (K +-deficient nutrient solution (60 μM K +) added with 100 mM NaCl). Results showed that all treatments applied led to a significant decrease of roo...
Plants have been seen to possess the potential to be excellent biological matrices to serve as a ... more Plants have been seen to possess the potential to be excellent biological matrices to serve as a basis for investigating the presence of promising therapeutic agents for cancer treatment. Several successful anti-cancer medicines - or their analogues - nowadays in use are plant derived and many more are under clinical trials. Under current circumstances, the purpose of this work was to test aqueous and ethanolic extracts of five aromatic and medicinal plants from arid zones on some tumor cell lines. These plants, Cymbopogon schoenanthus (L.) Spreng, Crithmum maritimum (L.) Spreng, Hammada scoparia (Pomel) Iljin, Retama raetam (Forssk.) and Zizyphus lotus (L.) Desf., widely used in Tunisian ethnomedicine, were assessed for their phenolic compounds, antioxidants and anticancer activities in aqueous and ethanol extracts. Total polyphenols, flavonoid and tannin contents were determined colorimetrically and some of these molecules were identified using RP-HPLC. A significant difference on...
Microencapsulation - Processes, Technologies and Industrial Applications [Working Title]
The microencapsulation technology consists of a trap of a compound inside a tiny sphere known as ... more The microencapsulation technology consists of a trap of a compound inside a tiny sphere known as microsphere. The microencapsulation concerns many different active materials such as bioactive compounds, drugs, vitamins, enzymes, flavors, and pesticides. This technology has gained real interest in numerous fields such as agriculture, cosmetic, pharmaceutical, textile, and food. This chapter highlights the encapsulation of essential oils into nanoemulsion-based delivery system as a model for the encapsulation of natural bioactive compounds. Moreover, an investigation of different parameters affecting the stability of produced nanoemulsion was conducted, in addition to the study of the effect of the nanoencapsulation of essential oils on their antibacterial activity. Finally, an enumeration of the advantages of encapsulating essential oils into nanoemulsion-based delivery systems in order to provide a natural food preservatives has been provided.
In Ben Mansour et al. (2018), the reference Kechairi and Abdoun (2016) was cited in Figure 1 capt... more In Ben Mansour et al. (2018), the reference Kechairi and Abdoun (2016) was cited in Figure 1 caption, however the complete reference information was missing in the reference list. The complete reference is as shown below.
Journal of Natural Product Research and Applications
Thymelaea microphylla is an edible and medicinal species that exhibits high antioxidant activity ... more Thymelaea microphylla is an edible and medicinal species that exhibits high antioxidant activity and phenolic content. Moreover, four fractions (hexane, dichloromethane, methanol and water) were tested towards their ex-vivo antioxidant, anticancer, anti-inflammatory and antiviral effects. Dichloromethane fraction had marked protection against cell oxidative stress (IC50 = 1.5 µg/mL). Hexane, Dichloromethane and Methanol fractions exhibited prominent anti-proliferative activities against cancer cells especially A-549 cells, with very low IC50 values of 0.13, 0.018 and 0.5 µg/mL, respectively (50, 101 and 14 higher than Etoposide). Moreover, the three fractions showed no cytotoxicity on normal fibroblast WS-1. DCM exhibited high anti-inflammatory activity in RAW 264.7 cells. Theses fractions were also tested on herpes (HSV-1). MeOH fraction was the most active acting both directly on the virus and on its adsorption. Phenolics, terpenoids and saponins were the major classes. These find...
Six medicinal halophytes widely represented in North Africa and commonly used in traditional medi... more Six medicinal halophytes widely represented in North Africa and commonly used in traditional medicine were screened for pharmacological properties to set out new promising sources of natural ingredients for cosmetic or nutraceutical applications. Thus, Citrullus colocynthis, Cleome arabica, Daemia cordata, Haloxylon articulatum, Pituranthos scoparius and Scorzonera undulata were examined for their in vitro antioxidant (DPPH scavenging and superoxide anion-scavenging, β-carotene bleaching inhibition and iron-reducing tests), antibacterial (microdilution method, against four human pathogenic bacteria) and anti-tyrosinase activities. Besides, their aromatic composition was determined by RP-HPLC. H. articulatum shoot extracts exhibited the strongest antioxidant activity and inhibited efficiently the growth of Salmonella enterica and Escherichia coli. P. scoparius and C. arabica inhibited slightly monophenolase, whereas H. articulatum was the most efficient inhibitor of diphenolase activ...
Polyphenols are bioactive molecules exhibiting a lot of scientific attention due to their multipl... more Polyphenols are bioactive molecules exhibiting a lot of scientific attention due to their multiple biological activities. This study compared phenolic contents and antioxidant activity in Cynara cardunculus L. organs and focus on leaf phenolic compounds identification by RP-HPLC and their antibacterial activity. The analyzed organs exhibited different total polyphenol contents (7– 14.8 mg GAE g −1 DW). Leaf and seed phenolic contents were similar and two times higher than those in flowers. The same tendency was observed for the amount of flavonoids and tannins. However, seed extracts displayed the highest DPPH · scavenging ability with the lowest IC50 value (23 µg ml −1 ), followed by leaves and flowers (over 50 µg ml −1 ). In contrast, leaves showed the highest capacity to quench superoxide (IC50 :1µ g ml −1 ) as compared to seeds (6 µg ml −1 ). In addition, cardoon leaves were efficient to inhibit growth of pathogenic bacteria mainly against Staphylococcus aureus and Escherichia c...
Salinity and potassium deficiency are major abiotic constraints affecting plant growth, productiv... more Salinity and potassium deficiency are major abiotic constraints affecting plant growth, productivity, and metabolism. The present work was conducted to check whether salinity alleviates, aggravates, or does not affect the effects of potassium deficiency on Sulla carnosa , a salt-tolerant legume common in diverse saline soils. We investigated the changes in plant growth, phenolic compound composition, and antioxidant activity in stems and roots of this species grown hydroponically under different conditions: C, control (complete nutrient solution containing 6 mM K + and not added with NaCl); KD, K + deficiency (K + -deficient nutrient solution (60 μM K + ) not added with NaCl); C + S, salt treatment (control nutrient solution containing 6 mM K + and added with 100 mM NaCl); and KD + S, combined treatment between salinity and K + deficiency (K + -deficient nutrient solution (60 μM K + ) added with 100 mM NaCl). Results showed that all treatments applied led to a significant decrease of root and stem growth, with a more marked reduction in plants exposed to the combined stresses, suggesting synergistic effects of salinity and K + deficiency. In addition, results indicated that both stresses either applied alone or in combination quantitatively or qualitatively modulated phenolic compound accumulation and their antioxidant activities. But a predominance of K + deficiency effect was noticed, which may be considered as a suitable manipulation for the production of antioxidants compared to the other treatments.
This work focuses on the variability of Retama raetam (Forssk.) Webb bioactive compounds as a fun... more This work focuses on the variability of Retama raetam (Forssk.) Webb bioactive compounds as a function of the plant cycle. The main results showed that it exhibited the highest percentage of polyunsaturated fatty acids, along with superior levels of vitamin C and total phenolic compounds (66.49%, 645.6 mg·100 g−1 FW and 23.9 mg GAE·g−1, respectively) at the vegetative stage. Instead, at the flowering and mature fruiting stages, R. raetam (Forssk.) Webb exhibited notable contents of proline (25.4 μmol·g−1 DW) and carotenoids (27.2 μg·g−1 FW), respectively. The gathered data concerning the antioxidant activity highlighted the effectiveness of the vegetative stage in comparison to the other periods. Actually, IC50 and EC50 values of the hydromethanolic extract obtained from the plant shoots at the vegetative stage were of 23, 380, 410, 1160 and 960 μg·mL−1 (DPPH• and ABTS•+ radicals scavenging activity, reducing power, chelating power and β-carotene bleaching activity, respectively). F...
Total phenol content and the antioxidant activities of three cultivars of Opuntia ficus-indica (L... more Total phenol content and the antioxidant activities of three cultivars of Opuntia ficus-indica (L.) Mill. were evaluated. The results show that the ecotypes were significantly different according to their fatty acid composition, antioxidant and antibacterial activity, as well as their polyphenol profiles. Rossa fruit collected in August exhibited the higher phenolic content (15.48 mg GAE g −1 DW) with a stronger antioxidant activity. Bianca fruit collected in August exhibited a lower phenolic content (3.13 mg GAE g −1 DW) together with the stronger antiradical activity (96.14%). The advantage of this ecotype was more discernible as compared to positive controls butylated hydroxytoluene (BHT, 79.75%). Likewise, CpG chromatogram identification revealed also an important difference between the ecotypes on oleic and linoleic acids.
Antioxidants are the chemical substances that reduce or prevent oxidation. The present study aime... more Antioxidants are the chemical substances that reduce or prevent oxidation. The present study aimed to assess in vitro and ex vivo antioxidant activities of four acetonic extracts Tunisian halophytes (Suaeda fruticosa, Suaeda pruinosa, Suaeda mollis and Suaeda maritima). Various experimental models were used for characterization of antioxidant activities of shoot extracts. Eventually, the promising specie was subjected to phenolic identification using RP-HPLC. The analyzed shoot extracts exhibited that antioxidant activities varied considerably as function of species. The highest DPPH • scavenging ability was found in S. mollis with the lowest IC 50 value (2.5 g/ml), followed by S. pruinosa, S. fruticosa and S. maritima. The same tendency was observed with ferric reducing power. Concerning -carotene bleaching assays and total antioxidant activity, results showed that S. fruticosa exhibited the highest antioxidant ability against the inhibition of -carotene bleaching, and a better total antioxidant capacity. Moreover antioxidant capacities using ORAC method and a cell based-assay showed that S. mollis, S. fruticosa, and S. pruinosa exhibit statistically similar antioxidant activity. The identification of phenolic compounds in S. mollis extract using RP-HPLC revealed that 2,5-dihydroxybenzoic acid and rutin hydrate were the major molecules. These results suggested that Suaeda species showed a variability of their antioxidant activities.
Depuis la nuit des temps, les plantes ont été la source principale de molécules bioactives, tels ... more Depuis la nuit des temps, les plantes ont été la source principale de molécules bioactives, tels les composés phénoliques, capables de remédier à diverses maladies. Cependant, le contenu et l’activité des polyphénols dépendent d’un certain nombre de facteurs intrinsèques et extrinsèques. Dans le but d’optimiser les procédés d’obtention des principes actifs de la verveine (Verbena officinalis), les effets de la provenance de la plante, du solvant et de la méthode d’extraction ont été évalués. Ainsi, la partie aérienne de V. officinalis a été collectée dans deux régions différentes de la Tunisie (Bizerte et Ain Draham). L’extraction a été réalisée par macération, décoction et par l’appareil de Soxhlet tantôt avec de l’eau tantôt avec de l’éthanol pur. Une variabilité significative des teneurs en composés phénoliques ainsi que des capacités antioxydantes et antimicrobiennes des extraits a été observée en fonction des facteurs étudiés. De manière générale, les extraits éthanoliques sont...
Introduction. Essential oils and their components are currently of great interest as a potential ... more Introduction. Essential oils and their components are currently of great interest as a potential source of highly bioactive natural molecules. They are being studied for their possible use as safe alternative for food protection against oxidation and microbial spoilage. Objective. This study aimed on the phytochemical prospection of Thymus capitatus and Rosmainus officinalis essential oils and their oral toxicity evaluation. Material and methods. Chemical analysis of tested essential oils was carried out using gas chromatography combined to mass spectroscopic (GC-MS). Their safety limit was evaluated by acute toxicity. The antioxidant activity was estimated using in vitro methods. The antimicrobial activity was evaluated against twelve pathogenic germs. Results. Results showed that carvacrol and 1,8-cineol were the major compounds of Thymus capitatus and Rosmarinus officinalis essential oils. Acute toxicity results exhibited that both tested essential oils were inoffensive at 2000 m...
Mesembryanthemum edule is used as a food ingredient and in traditional medicine. In this study, w... more Mesembryanthemum edule is used as a food ingredient and in traditional medicine. In this study, we investigated antioxidant activities of several extracts (methanol/acidified water, v/v: 20/80; 40/60 and 60/40) obtained from M. edule leaf, stem and root. Then, individual phenolics were characterised by reversephase HPLC coupled to electrospray ionisation mass spectrometry and multi-stage MS fragment analysis. Results showed that 40% methanol leaf extract, 40% methanol root extract and 20% methanol stem extract displayed the highest scavenging activity against DPPH and ABTS radicals. Regarding LC/ESI-MS/MS identification of active phenols, there were significant differences among the fractions of interest. In fact, 40% leaf extract mainly contained procyanidins, whereas propelargonidins were the major phenolics in 20% methanol stem extract, while, in 40% root extract, the active compounds remained unidentified. These results indicate that edible M. edule can be used as a nutraceutical in the pharmaceutical industry.
Salinity and potassium deficiency are major abiotic constraints affecting plant growth, productiv... more Salinity and potassium deficiency are major abiotic constraints affecting plant growth, productivity, and metabolism. The present work was conducted to check whether salinity alleviates, aggravates, or does not affect the effects of potassium deficiency on Sulla carnosa, a salt-tolerant legume common in diverse saline soils. We investigated the changes in plant growth, phenolic compound composition, and antioxidant activity in stems and roots of this species grown hydroponically under different conditions: C, control (complete nutrient solution containing 6 mM K + and not added with NaCl); KD, K + deficiency (K +-deficient nutrient solution (60 μM K +) not added with NaCl); C + S, salt treatment (control nutrient solution containing 6 mM K + and added with 100 mM NaCl); and KD + S, combined treatment between salinity and K + deficiency (K +-deficient nutrient solution (60 μM K +) added with 100 mM NaCl). Results showed that all treatments applied led to a significant decrease of roo...
Plants have been seen to possess the potential to be excellent biological matrices to serve as a ... more Plants have been seen to possess the potential to be excellent biological matrices to serve as a basis for investigating the presence of promising therapeutic agents for cancer treatment. Several successful anti-cancer medicines - or their analogues - nowadays in use are plant derived and many more are under clinical trials. Under current circumstances, the purpose of this work was to test aqueous and ethanolic extracts of five aromatic and medicinal plants from arid zones on some tumor cell lines. These plants, Cymbopogon schoenanthus (L.) Spreng, Crithmum maritimum (L.) Spreng, Hammada scoparia (Pomel) Iljin, Retama raetam (Forssk.) and Zizyphus lotus (L.) Desf., widely used in Tunisian ethnomedicine, were assessed for their phenolic compounds, antioxidants and anticancer activities in aqueous and ethanol extracts. Total polyphenols, flavonoid and tannin contents were determined colorimetrically and some of these molecules were identified using RP-HPLC. A significant difference on...
Microencapsulation - Processes, Technologies and Industrial Applications [Working Title]
The microencapsulation technology consists of a trap of a compound inside a tiny sphere known as ... more The microencapsulation technology consists of a trap of a compound inside a tiny sphere known as microsphere. The microencapsulation concerns many different active materials such as bioactive compounds, drugs, vitamins, enzymes, flavors, and pesticides. This technology has gained real interest in numerous fields such as agriculture, cosmetic, pharmaceutical, textile, and food. This chapter highlights the encapsulation of essential oils into nanoemulsion-based delivery system as a model for the encapsulation of natural bioactive compounds. Moreover, an investigation of different parameters affecting the stability of produced nanoemulsion was conducted, in addition to the study of the effect of the nanoencapsulation of essential oils on their antibacterial activity. Finally, an enumeration of the advantages of encapsulating essential oils into nanoemulsion-based delivery systems in order to provide a natural food preservatives has been provided.
In Ben Mansour et al. (2018), the reference Kechairi and Abdoun (2016) was cited in Figure 1 capt... more In Ben Mansour et al. (2018), the reference Kechairi and Abdoun (2016) was cited in Figure 1 caption, however the complete reference information was missing in the reference list. The complete reference is as shown below.
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