Stomach and Its Secretions
Stomach and Its Secretions
Stomach and Its Secretions
Dr Raghuveer
The Stomach
parietal cells: produce HCl and intrinsic factor G cells: produce hormones that regulate digestion
Gastrin secreted by G cells in gastric gland not into gastric juice but in blood is a hormone
stimulates
1) the secretion of HCl and pepsinogen 2) motility of the large intestine
MUCOUS SECRETION
The surface epithelial cells of the stomach secrete visible mucous (slightly opaque) that lines the surface of the stomach. Visible mucous contains crosslinked mucins (glycoproteins) that form an almost gelatinous coating which contains relatively high concentrations of bicarbonate ion
This coating protects the stomach epithelium from gastric acid and pepsin. Glycosylation of mucin makes it relatively resistant to proteolysis by pepsin.
Soluble mucous
A second type of mucous, soluble mucous, is secreted along with the gastric juice from the gastric pits to lubricate the food bolus and facilitate mixing. Soluble mucous also contains mucins, but they are not crosslinked, and consequently, produce a less viscous fluid.
HCl
1) a highly alkaline mucous coat. 2) rapid replacement of epithelial cells (3-6 d) 3) tight junctions between epithelial cells
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