Piperacillin Tazobactam
Piperacillin Tazobactam
PHARMACOLOGY
DRUG STUDY
Brand Name: ________________________________________________ Generic Name: _____________________________ Drug Classification: ___antiinfective; beta-lactam
antibiotic________________________________
Dosage, Route & Frequency Drug-Drug & Drug- Side Effects Adverse Reactions
Drug Action Indications Contraindications
Recommended Prescribed Food Interactions (By System) (By System)
Moderate to Severe: Antibacterial Drug: may increase Treatment of moderate Hypersensitvity to Swelling of the CNS: Headache,
Adult: IV 3.375g q6h, combination product risk of bleedings with to severe appendicitis, piperacilling, injection site Insomnia, fever
infused over 30min consisting of the anticoagulant; uncomplicated and skin tazobactam,
for 7-10 d semisynthetic piperacillin
probenecid decreases and kin structure
penicillines, Agitation GI: Diarrhea,
and the beta-lactamaze infections, endometritis, Constipation, Nausea,
Child: IV <6 mo, 150- elimination of cephalosporins or
inhibitor tazobactam. pelvic inflammatory Insomnia Vomitting, Dyspepsia,
300mg Tazobactam component piperacillin. disease or nosocomial or beta-lactamase
piperacillin/kg/d inhibitors such as Pseudomembranous
doesnot decrease the community-acquired Abdominal pain
divided q6-8h; 6mo, activity of the piperacillin pneumonia caused by clavulanic acid and colitis
240mg piperacillin component against piperacillin-resistant, sulbactam. Runny nose
SKIN: Rash, Pruritus,
component/ kg/d susceptible organisms. piperacilline/
tazobactam-susceptible, Hypersensitivity
divided q8h
beta-lactamase- reactions
Nosocomial producing bacteria.
Pneumonia
Adult: IV 4.5g q6h,
infused over 30min,
for 7-10d
Renal Insuffieciency
Clcr 20-40mL/MIN:
2.25G Q6H; <20
mL/min: 2.25 g q8h
Responsibilities in the Nursing Process (ADPIE) Responsibilities in the Nursing Process (ADPIE)
Assessment: obtain history of hypersensitivity to penicillins, cephalosporins or other drugs prior
to administration; Lab test: C&S prior to first to first dose of the drug; Monitor hematologic status
with prolonged therapy
Nursing Diagnosis: Acute pain r/t to obstruction of proximal lumen of the Appendix
Implementation: Keep patient well hydrated; Reconstitute powder with 5 mL of diluent (D5W,
NS); Shake well until dissolved. Further dilute to at least 50 mL of selected diluent. Use single-
dose vials immediately after reconstitution.