Test Report: Pass. No.
Test Report: Pass. No.
Test Report: Pass. No.
Reg. No. : 40602702472Reg. Date : 22-Jun-2024 19:15 Ref.No : Approved On : 22-Jun-2024 21:15
Name : Mrs. RENU GURUNG Collected On : 22-Jun-2024 19:17
Age : 42 Years Gender: Female Pass. No. : Dispatch At :
Ref. By : DR. A. BHANDARI Tele No. :
Location : SHIVSHAKTI DIAGNOSTICS @ SILIGURI
Normally triiodothyronine (T3) circulates tightly bound to thyroxine-binding globulin and albumin. Only 0.3% of the total T3 is unbound (free); the free fraction is
the active form. In hyperthyroidism, both thyroxine (tetraiodothyronine; thyroxine: T4) and T3 levels (total and free) are usually elevated, but in a small subset of
hyperthyroid patients (T3 toxicosis) only T3 is elevated. Generally, free T3 (FT3) measurement is not necessary since total T3 will suffice. However, FT3 levels may
be required to evaluate clinically euthyroid patients who have an altered distribution of binding proteins (eg, pregnancy, dysalbuminemia). Some investigators
recommend the FT3 assay for monitoring thyroid replacement therapy.
Method:ECLIA
Useful for evaluation of suspected thyroid function disorders using free thyroxine measured together with thyroid-stimulating hormone. FT4 is metabolically active
fraction. Elevated values suggest hyperthyroidism or exogenous thyroxine. Decreased values suggest hypothyroidism. Free thyroxine (FT4) works well to correct
total T4 values for thyroxine-binding globulin alterations, but may give misleading values when abnormal binding proteins are present or the patient has other
major illnesses (euthyroid sick syndrome).
Serum
Thyroid stimulating hormone (TSH) is synthesized and secreted by the anterior pituitary in response to a negative feedback mechanism involving concentrations of
FT3 (free T3) and FT4 (free T4). Additionally, the hypothalamic tripeptide, thyrotropin-relasing hormone (TRH), directly stimulates TSH production. TSH stimulates
thyroid cell production and hypertrophy, also stimulate the thyroid gland to synthesize and secrete T3 and T4. Quantification of TSH is significant to differentiate
primary (thyroid) from secondary (pituitary) and tertiary (hypothalamus) hypothyroidism. In primary hypothyroidism, TSH levels are significantly elevated, while in
secondary and tertiary hypothyroidism, TSH levels are low..
TSH levels During Pregnancy : First Trimester :0.1 to 2.5 µIU/mL
Second Trimester : 0.2 to 3.0 µIU/mL
Third trimester : 0.3 to 3.0 µIU/mL
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