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Typhoid fever
SECTIONSFOR TYPHOID FEVER
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Overview
Typhoid fever is caused by Salmonella typhi bacteria. Typhoid fever is rare in
developed countries. It is still a serious health threat in the developing world, especially
for children.
Contaminated food and water or close contact with an infected person cause
typhoid fever. Signs and symptoms usually include:
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 High fever
 Headache
 Stomach pain
 Constipation or diarrhea
Most people who have typhoid fever feel better a few days after they start
antibiotic treatment, but a small number of them may die of complications. Vaccines
against typhoid fever are only partially effective. Vaccines usually are reserved for those
who may be exposed to the disease or who are traveling to areas where typhoid fever is
common.
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Symptoms
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Signs and symptoms are likely to develop gradually — often appearing one to
three weeks after exposure to the disease.
Early illness
Signs and symptoms include:
 Fever that starts low and increases daily, possibly reaching as high as 104.9 F (40.5 C)
 Headache
 Weakness and fatigue
 Muscle aches
 Sweating
 Dry cough
 Loss of appetite and weight loss
 Stomach pain
 Diarrhea or constipation
 Rash
 Extremely swollen stomach
Later illness
Without treatment, you may:
 Become delirious
 Lie motionless and exhausted with your eyes half-closed in what's known as the typhoid
state
Life-threatening complications often develop at this time.
In some people, signs and symptoms may return up to two weeks after the fever
has subsided.
When to see a doctor

See a doctor immediately if you think you might have typhoid fever. If you live in
the United States and become sick while traveling in a foreign country, call the U.S.
Consulate for a list of doctors.
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If you have signs and symptoms after you return home, consider seeing a doctor
who focuses on international travel medicine or infectious diseases. A doctor who is
familiar with these areas may be able to recognize and treat your illness more quickly.
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Causes
Typhoid fever is caused by dangerous bacteria called Salmonella typhi.
Salmonella typhi is related to the bacteria that cause salmonellosis, another serious
intestinal infection, but they aren't the same.
Fecal-oral transmission route

Most people in developed countries pick up typhoid bacteria while they're
traveling. Once they have been infected, they can spread it to others through the fecal-
oral route.
This means that Salmonella typhi is passed in the feces and sometimes in the
urine of infected people. If you eat food that has been handled by someone who has
typhoid fever and who hasn't washed carefully after using the toilet, you can become
infected.
In developing countries, where typhoid fever is established, most people become

infected by drinking contaminated water. The bacteria may also spread through
contaminated food and through direct contact with someone who is infected.
Typhoid carriers
Even after antibiotic treatment, a small number of people who recover from
typhoid fever continue to harbor the bacteria. These people, known as chronic carriers,
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no longer have signs or symptoms of the disease themselves. However, they still shed
the bacteria in their feces and are capable of infecting others.
Risk factors
Typhoid fever is a serious worldwide threat and affects about 27 million or more
people each year. The disease is established in India, Southeast Asia, Africa, South
America and many other areas.
Worldwide, children are at greatest risk of getting the disease, although they
generally have milder symptoms than adults do.
If you live in a country where typhoid fever is rare, you're at increased risk if you:
 Work in or travel to areas where typhoid fever is established
 Work as a clinical microbiologist handling Salmonella typhi bacteria
 Have close contact with someone who is infected or has recently been infected with
typhoid fever
 Drink water polluted by sewage that contains Salmonella typhi
Complications
Intestinal bleeding or holes
Intestinal bleeding or holes in the intestine are the most serious complications of
typhoid fever. They usually develop in the third week of illness. In this condition, the
small intestine or large bowel develops a hole. Contents from the intestine leak into the
stomach and can cause severe stomach pain, nausea, vomiting and bloodstream
infection (sepsis). This life-threatening complication requires immediate medical care.
Other, less common complications

Other possible complications include:
 Inflammation of the heart muscle (myocarditis)
 Inflammation of the lining of the heart and valves (endocarditis)
 Infection of major blood vessels (mycotic aneurysm)
 Pneumonia
 Inflammation of the pancreas (pancreatitis)
 Kidney or bladder infections

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 Infection and inflammation of the membranes and fluid surrounding your brain and spinal
cord (meningitis)
 Psychiatric problems, such as delirium, hallucinations and paranoid psychosis
With quick treatment, nearly all people in industrialized nations recover from
typhoid fever. Without treatment, some people may not survive complications of the
disease.
Prevention
Safe drinking water, improved sanitation and adequate medical care can help
prevent and control typhoid fever. Unfortunately, in many developing nations, these may
be difficult to achieve. For this reason, some experts believe that vaccines are the best
way to control typhoid fever.
A vaccine is recommended if you live in or are traveling to areas where the risk of
getting typhoid fever is high.
Vaccines
Two vaccines are available.
 One is given as a single shot at least one week before travel.
 One is given orally in four capsules, with one capsule to be taken every other day.
Neither vaccine is 100% effective. Both require repeat immunizations because

their effectiveness wears off over time.
Because the vaccine won't provide complete protection, follow these guidelines
when traveling to high-risk areas:
 Wash your hands. Frequent hand-washing in hot, soapy water is the best way to control
infection. Wash before eating or preparing food and after using the toilet. Carry an alcohol-
based hand sanitizer for times when water isn't available.
 Avoid drinking untreated water. Contaminated drinking water is a particular

problem in areas where typhoid fever is endemic. For that reason, drink only
bottled water or canned or bottled carbonated beverages, wine and beer.
Carbonated bottled water is safer than non-carbonated bottled water.
Ask for drinks without ice. Use bottled water to brush your teeth, and try not
to swallow water in the shower.
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 Avoid raw fruits and vegetables. Because raw produce may have been washed in
contaminated water, avoid fruits and vegetables that you can't peel, especially lettuce. To
be absolutely safe, you may want to avoid raw foods entirely.
 Choose hot foods. Avoid food that's stored or served at room temperature. Steaming hot
foods are best. And although there's no guarantee that meals served at the finest
restaurants are safe, it's best to avoid food from street vendors — it's more likely to be
infected.
 Know where the doctors are. Find out in advance about medical care in the areas you'll
visit, and carry a list of the names, addresses and phone numbers of recommended
doctors.
Prevent infecting others

If you're recovering from typhoid fever, these measures can help keep others
safe:
 Take your antibiotics. Follow your doctor's instructions for taking your antibiotics, and be
sure to finish the entire prescription.
 Wash your hands often. This is the single most important thing you can do to keep from
spreading the infection to others. Use hot, soapy water and scrub thoroughly for at least
30 seconds, especially before eating and after using the toilet.
 Avoid handling food. Avoid preparing food for others until your doctor says you're no
longer contagious. If you work in the food service industry or a health care facility, you
won't be allowed to return to work until tests show that you're no longer shedding typhoid
bacteria.

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SECTIONSFOR TYPHOID FEVER

 Book: Mayo Clinic Family Health Book, 5th Edition

 Weakness and fatigue

 Loss of appetite and weight loss

 Extremely swollen stomach

Life-threatening complications often develop at this time.

When to see a doctor

Request an Appointment at Mayo Clinic

From Mayo Clinic to your inbox

Learn more about Mayo Clinic’s use of data.

Fecal-oral transmission route

In developing countries, where typhoid fever is established, most people become

 Work in or travel to areas where typhoid fever is established

 Work as a clinical microbiologist handling Salmonella typhi bacteria

 Drink water polluted by sewage that contains Salmonella typhi

Other, less common complications

 Inflammation of the heart muscle (myocarditis)

 Inflammation of the lining of the heart and valves (endocarditis)

 Infection of major blood vessels (mycotic aneurysm)

 Inflammation of the pancreas (pancreatitis)

 Kidney or bladder infections

 Psychiatric problems, such as delirium, hallucinations and paranoid psychosis

 One is given as a single shot at least one week before travel.

Neither vaccine is 100% effective. Both require repeat immunizations because

 Avoid drinking untreated water. Contaminated drinking water is a particular

Prevent infecting others

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