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Receptors Involved in Breathing

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2 views

Receptors Involved in Breathing

Uploaded by

b4hwcjzmpy
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Ventilation Control – Chemical

• Goal: O2 & CO2 level homeostasis

• Regulated by concentrations of CO2, O2,


and pH (H+)

• Central chemoreceptors
• Found in medulla

• Peripheral chemoreceptors
• Found in aortic arch & carotid arteries

1
Fig. 22.15
Ventilation Control – Chemical
• Peripheral - Glomus cells
• Found in aortic arch & carotid arteries
• Respond to changes in CO2, O2, and pH
levels in blood
• Trigger increase in ventilation when O2
levels drop significantly

2
Fig. 21.27
Ventilation Control – Chemical

• Central chemoreceptors in medulla respond to changes in pH of


cerebrospinal fluid

3
Ventilation Control – Chemical

• Central chemoreceptors in medulla respond to changes in pH of


cerebrospinal fluid

Peripheral
mechanisms

4
Stretch Receptors
• Located in the smooth muscle lining of
some of the large conducting airways like
bronchi and bronchioles
• Respond when bronchioles are inflated or
stretched
• Main stimulus appears to be the rate of change
of lung stretch
• Signal DRG via vagus nerve
• Excessive inflation → inhibition of inspiratory
neurons of VRG

Fig. 22.7
Irritant Receptors
• Nerve endings integrated in respiratory
epithelium
• Respond to irritants (ex: smoke, dust,
pollen, cold, excess mucus)
• Signal DRG via vagus nerve
• Irritation → bronchoconstriction, shallow
breathing, breath holding, and coughing

Fig. 22.7
Ventilation Control

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