Scribd Logo
Upload

Welcome to Scribd!

  • 34 views

    Dye and Drug Delivery With Phage-Like Nanoparticles

    Uploaded by

    U.S. Naval Research Laboratory
    The Naval Research Laboratory (NRL) has developed phage-like nanoparticles for the delivery of payloads to targeted eukaryotic cells. The nanoparticles are designed with reactive surface groups that can bind a dye, drug, antibody, etc. The modified nanoparticles can be used for cell tracking, cell imaging, and drug delivery. They are produced from E. coli as tailless T4 bacteriophage and modified to deliver content into targeted eukaryotic cells. In testing conditions, the nanoparticles can retain their shape in the absence of DNA. The tailless bacteriophage is non-contagious, non-toxic, and biodegradable. These features enable it to be used for in vitro diagnostics and potentially for in vivo applications. Dyes delivered by the nanoparticles can aid in intracellular imaging and cell tracking. Because of their size, these nanoparticles have the advantage of being able to deliver a substantial amount of treatment directly to a specified cell, such as a tumor cell. Studies have confirmed that the nanoparticles are non-toxic to human umbilical endothial cells, astrocytes, and liver cells. The nanoparticles have been shown to effectively deliver fluorescent dyes, such as Cy3 and AlexaFluor546. These phage-like nanoparticles have great potential for use in biomedical applications. NRL Technology Transfer Office http://www.nrl.navy.mil/techtransfer/fs.php?fs_id=BIO10 Naval Research Laboratory website http://www.nrl.navy.mil

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd

    Dye and Drug Delivery With Phage-Like Nanoparticles

    Uploaded by

    U.S. Naval Research Laboratory
    34 views1 page
    The Naval Research Laboratory (NRL) has developed phage-like nanoparticles for the delivery of payloads to targeted eukaryotic cells. The nanoparticles are designed with reactive surface groups that can bind a dye, drug, antibody, etc. The modified nanoparticles can be used for cell tracking, cell imaging, and drug delivery. They are produced from E. coli as tailless T4 bacteriophage and modified to deliver content into targeted eukaryotic cells. In testing conditions, the nanoparticles can retain their shape in the absence of DNA. The tailless bacteriophage is non-contagious, non-toxic, and biodegradable. These features enable it to be used for in vitro diagnostics and potentially for in vivo applications. Dyes delivered by the nanoparticles can aid in intracellular imaging and cell tracking. Because of their size, these nanoparticles have the advantage of being able to deliver a substantial amount of treatment directly to a specified cell, such as a tumor cell. Studies have confirmed that the nanoparticles are non-toxic to human umbilical endothial cells, astrocytes, and liver cells. The nanoparticles have been shown to effectively deliver fluorescent dyes, such as Cy3 and AlexaFluor546. These phage-like nanoparticles have great potential for use in biomedical applications. NRL Technology Transfer Office http://www.nrl.navy.mil/techtransfer/fs.php?fs_id=BIO10 Naval Research Laboratory website http://www.nrl.navy.mil

    Original Title

    Dye and Drug Delivery with Phage-Like Nanoparticles

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The Naval Research Laboratory (NRL) has developed phage-like nanoparticles for the delivery of payloads to targeted eukaryotic cells. The nanoparticles are designed with reactive surface groups that can bind a dye, drug, antibody, etc. The modified nanoparticles can be used for cell tracking, cell imaging, and drug delivery. They are produced from E. coli as tailless T4 bacteriophage and modified to deliver content into targeted eukaryotic cells. In testing conditions, the nanoparticles can retain their shape in the absence of DNA. The tailless bacteriophage is non-contagious, non-toxic, and biodegradable. These features enable it to be used for in vitro diagnostics and potentially for in vivo applications. Dyes delivered by the nanoparticles can aid in intracellular imaging and cell tracking. Because of their size, these nanoparticles have the advantage of being able to deliver a substantial amount of treatment directly to a specified cell, such as a tumor cell. Studies have confirmed that the nanoparticles are non-toxic to human umbilical endothial cells, astrocytes, and liver cells. The nanoparticles have been shown to effectively deliver fluorescent dyes, such as Cy3 and AlexaFluor546. These phage-like nanoparticles have great potential for use in biomedical applications. NRL Technology Transfer Office http://www.nrl.navy.mil/techtransfer/fs.php?fs_id=BIO10 Naval Research Laboratory website http://www.nrl.navy.mil

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    34 views1 page

    Dye and Drug Delivery With Phage-Like Nanoparticles

    Uploaded by

    U.S. Naval Research Laboratory
    The Naval Research Laboratory (NRL) has developed phage-like nanoparticles for the delivery of payloads to targeted eukaryotic cells. The nanoparticles are designed with reactive surface groups that can bind a dye, drug, antibody, etc. The modified nanoparticles can be used for cell tracking, cell imaging, and drug delivery. They are produced from E. coli as tailless T4 bacteriophage and modified to deliver content into targeted eukaryotic cells. In testing conditions, the nanoparticles can retain their shape in the absence of DNA. The tailless bacteriophage is non-contagious, non-toxic, and biodegradable. These features enable it to be used for in vitro diagnostics and potentially for in vivo applications. Dyes delivered by the nanoparticles can aid in intracellular imaging and cell tracking. Because of their size, these nanoparticles have the advantage of being able to deliver a substantial amount of treatment directly to a specified cell, such as a tumor cell. Studies have confirmed that the nanoparticles are non-toxic to human umbilical endothial cells, astrocytes, and liver cells. The nanoparticles have been shown to effectively deliver fluorescent dyes, such as Cy3 and AlexaFluor546. These phage-like nanoparticles have great potential for use in biomedical applications. NRL Technology Transfer Office http://www.nrl.navy.mil/techtransfer/fs.php?fs_id=BIO10 Naval Research Laboratory website http://www.nrl.navy.mil

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 1

    R

    ES

    EARCH LA B

    AL

    NAVAL RESEARCH LABORATORY


    TECHNOLOGY LICENSING OPPORTUNITY

    R
    AT

    NAV

    ORY

    AS

    HINGTO

    N,

    DYE AND DRUG DELIVERY WITH PHAGE-LIKE NANOPARTICLES


    Advantages/Features Recovers from E. coli with >90% purity Uses commercially available equipment and techniques for large-scale production Accommodates 1.9 x 10 dyes per nanoparticle, better than TMV or PVX Delivers effective fluorescence in vitro with as few as 350 dyes per particle Accumulates in cells for at least 72 hours Applications Drug delivery vehicle Cellular imaging in vitro and in vivo Cell tracking in co-cultures Fluorescence-activated cell sorting (FACS) Other flow cytometry applications For more information contact: Rita Manak, Ph.D. Head, Technology Transfer Office 202 767-3083 rita.manak@nrl.navy.mil References Identification Number: BIO10 "Engineered T4 Viral Nanoparticles for Cellular Imaging and Flow Cytometry," Bioconjugate Chemistry, 2001, 22, p. 595-604. Available for License: Patent applications have been filed.
    4

    The Naval Research Laboratory (NRL) has developed phage-like nanoparticles for the delivery of payloads to targeted eukaryotic cells. The nanoparticles are designed with reactive surface groups that can bind a dye, drug, antibody, etc. The modified nanoparticles can be used for cell tracking, cell imaging, and drug delivery. They are produced from E. coli as tailless T4 bacteriophage and modified to deliver content into targeted eukaryotic cells. In testing conditions, the nanoparticles can retain their shape in the absence of DNA. The tailless bacteriophage is non-contagious, non-toxic, and biodegradable. These features enable it to be used for in vitro diagnostics and potentially for in vivo applications. Dyes delivered by the nanoparticles can aid in intracellular imaging and cell tracking. Because of their size, these nanoparticles have the advantage of being able to deliver a substantial amount of treatment directly to a specified cell, such as a tumor cell. Studies have confirmed that the nanoparticles are non-toxic to human umbilical endothial cells, astrocytes, and liver cells. The nanoparticles have been shown to effectively deliver fluorescent dyes, such as Cy3 and AlexaFluor546. These phage-like nanoparticles have great potential for use in biomedical applications.

    ES

    EARCH LA

    BO

    AL

    AT

    NAV

    ORY

    technology

    AS

    HING TON,

    You might also like

    pFad - Phonifier reborn

    Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

    Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


    Alternative Proxies:

    Alternative Proxy

    pFad Proxy

    pFad v3 Proxy

    pFad v4 Proxy