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    Novel Sheath Flow Method

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    U.S. Naval Research Laboratory
    The Naval Research Laboratory (NRL) has developed a low cost, miniaturized, micro -fluidic approach to sheath flow systems used particularly in cytometery. The system utilizes a core stream and one or more sheath streams that are introduced into a single channel. The simple and straight-forward fabrication allows one or more grooves placed in the top and bottom of the channel, which directs the sheath fluid around the core stream, and separates the core stream from the walls of the channel. The patented NRL technique avoids the use of a nozzle or other constriction mechanism typically used, which can present issues with clogging. The sheath flow system completely surrounds the core stream, yet the fabrication of materials is simple and can be made from multiple materials. The system is reversible, which can be used to unsheathe the sheathed flow and recapture the core and sheath with high efficiency. NRL Technology Transfer Office http://www.nrl.navy.mil/techtransfer/fs.php?fs_id=BIO05 Naval Research Laboratory website http://www.nrl.navy.mil

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    Novel Sheath Flow Method

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    U.S. Naval Research Laboratory
    41 views1 page
    The Naval Research Laboratory (NRL) has developed a low cost, miniaturized, micro -fluidic approach to sheath flow systems used particularly in cytometery. The system utilizes a core stream and one or more sheath streams that are introduced into a single channel. The simple and straight-forward fabrication allows one or more grooves placed in the top and bottom of the channel, which directs the sheath fluid around the core stream, and separates the core stream from the walls of the channel. The patented NRL technique avoids the use of a nozzle or other constriction mechanism typically used, which can present issues with clogging. The sheath flow system completely surrounds the core stream, yet the fabrication of materials is simple and can be made from multiple materials. The system is reversible, which can be used to unsheathe the sheathed flow and recapture the core and sheath with high efficiency. NRL Technology Transfer Office http://www.nrl.navy.mil/techtransfer/fs.php?fs_id=BIO05 Naval Research Laboratory website http://www.nrl.navy.mil

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    The Naval Research Laboratory (NRL) has developed a low cost, miniaturized, micro -fluidic approach to sheath flow systems used particularly in cytometery. The system utilizes a core stream and one or more sheath streams that are introduced into a single channel. The simple and straight-forward fabrication allows one or more grooves placed in the top and bottom of the channel, which directs the sheath fluid around the core stream, and separates the core stream from the walls of the channel. The patented NRL technique avoids the use of a nozzle or other constriction mechanism typically used, which can present issues with clogging. The sheath flow system completely surrounds the core stream, yet the fabrication of materials is simple and can be made from multiple materials. The system is reversible, which can be used to unsheathe the sheathed flow and recapture the core and sheath with high efficiency. NRL Technology Transfer Office http://www.nrl.navy.mil/techtransfer/fs.php?fs_id=BIO05 Naval Research Laboratory website http://www.nrl.navy.mil

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    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    41 views1 page

    Novel Sheath Flow Method

    Uploaded by

    U.S. Naval Research Laboratory
    The Naval Research Laboratory (NRL) has developed a low cost, miniaturized, micro -fluidic approach to sheath flow systems used particularly in cytometery. The system utilizes a core stream and one or more sheath streams that are introduced into a single channel. The simple and straight-forward fabrication allows one or more grooves placed in the top and bottom of the channel, which directs the sheath fluid around the core stream, and separates the core stream from the walls of the channel. The patented NRL technique avoids the use of a nozzle or other constriction mechanism typically used, which can present issues with clogging. The sheath flow system completely surrounds the core stream, yet the fabrication of materials is simple and can be made from multiple materials. The system is reversible, which can be used to unsheathe the sheathed flow and recapture the core and sheath with high efficiency. NRL Technology Transfer Office http://www.nrl.navy.mil/techtransfer/fs.php?fs_id=BIO05 Naval Research Laboratory website http://www.nrl.navy.mil

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    NAVAL RESEARCH LABORATORY


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    NOVEL SHEATH FLOW METHOD


    Advantages/Features Eliminates issues of clogging Ability to sheath high viscosity systems Fabricated in any material that can be machined or molded Efficient reversible system of sheathing and unsheathing Easily applied to liquid waveguides Applications Biomedical Research Water Monitoring Bioterrorist Defense Food and Polymer Extrusion For more information contact: Rita Manak, Ph.D. Head, Technology Transfer Office 202 767-3083 rita.manak@nrl.navy.mil Identification Number: BIO05

    The Naval Research Laboratory (NRL) has developed a low cost, miniaturized, micro -fluidic approach to sheath flow systems used particularly in cytometery. The system utilizes a core stream and one or more sheath streams that are introduced into a single channel.The simple and straight-forward fabrication allows one or more grooves placed in the top and bottom of the channel, which directs the sheath fluid around the core stream, and separates the core stream from the walls of the channel. The patented NRL technique avoids the use of a nozzle or other constriction mechanism typically used, which can present issues with clogging. The sheath flow system completely surrounds the core stream, yet the fabrication of materials is simple and can be made from multiple materials. The system is reversible, which can be used to unsheathe the sheathed flow and recapture the core and sheath with high efficiency.
    References "Two simple and rugged designs for creating microfluidic sheath" Lab Chip, 8, 1097-1103 (2008). "Multi-wavelength microflow cytometer using groove-generated sheath flow" Lab Chip, 9, 1942-1950 (2009) Available for License: US Patent Pub. Nos. 2009-0208372, 2011-0193259, and other applications have been filed.

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