Chromosome Mutation

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Genomazing Challenge!

1. Study Figure 1 (amino acid chart) and the DNA


sequences carefully, and read the captions very well.
Get a sheet of paper for your answers and observation.
Do not copy the questions, just write down your answer
or observations.
2. Study the following DNA strand: Transcribe and
Translate the original DNA strand:
DNA: A T G C C C G G C G A G
mRNA: _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
tRNA: _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
Mutations
• are changes to a DNA sequence. Just
like the information in DNA as a group of
sentences, mutations are mistakes in
spelling of the words that form those
sentences.
Mutagens
• are agents that cause alteration in the DNA
and can lead to permanent mutations in
the DNA sequence depending on the ability
of an organism to repair the damage.
• Examples of mutagens are radioactive
substances, x-rays, ultraviolet radiation,
and certain chemicals or drugs
Chromosomal Mutation
•is a change at the
chromosome level that
occurs during the cell
cycle and meiosis.
Types of chromosomal mutation
•Deletion
•Inversion
•Translocation
•Insertion
•Duplication
Types of chromosomal mutation

•Deletion
Types of chromosomal mutation

•Inversion
Types of chromosomal mutation

•Translocation
Types of chromosomal mutation

•Duplication
Types of chromosomal mutation

•Insertion
•Which of the chromosomal mutation
results to gain of chromosome material?
•What are some possible genetic
disorders for chromosomal deletion and
duplication?
•Which of the chromosomal mutation
results to loss of chromosome material?
•Can changes in the structure of
chromosomes affect an individual? How?
Genetic disorders

Guess the
syndrome
Guess the
syndrome
Cri du
chat
Guess the
syndrome
Down
syndrome
Guess the
syndrome
Edwards’s
syndrome
Guess the syndrome

Jacobsen syndrome
Guess the
syndrome
Klinefelters syndrome
Mark my Match
• Directions: Illustrations in column A are representations of the
different types of chromosomal mutation, examine the letters
on the original chromosome and compare it on the letters of
the mutated chromosome. Match the illustrations in Column A
with their corresponding type of mutation from Column B and
description from Column C. Write the letter of your answers on
the space provided.
Column A Column B Column C
Illustration Type of Mutation Description

ABCDEF E. Extra copies of part


Original chromosome
___, ___ 1. ACDEF A. Inversion of chromosome are
Mutated chromosome
made
ABCDEF
___, ___ 2. Original chromosome F. There is a lost part of
ABBCDEF B. Translocation the chromosome.
Mutated chromosome
ABCDEF G. These are reversed
___, ___ 3. Original chromosome
ACBDEF C. Duplication section of the
Mutated chromosome
chromosomes.

ABCDEF H. Part of one


___, ___ 4. \Original chromosome chromosome breaks off
ABGHCDEF D. Deletion and attaches to
Mutated chromosome another chromosome
What can You do?
• Directions: For the following activities, choose only one that you prefer to
accomplish. Use another sheet for your answer.
• 1. For example you are given a chance to be one of the representatives in the
“Down Syndrome Awareness Month Forum”. The activity is to write an
inspirational letter to your fellow youth and friends who are parents or relatives
of a person with Down syndrome. What are the words of inspiration that you
can give to them? You may use English or vernacular. (50-100 words)
• 2. Not all mutations are bad. There are naturally occurring genetic mutations
that can change the appearance and traits of flowers, fruit or stems of any plant
or crops and also, there are laboratory-made mutations. These mutations can
be designed by genetic engineers. Suppose you are a genetic engineer, what
gene or trait of a plant or crop are you going to design (duplicate, insert, or
delete) to help in food production or crop improvement? Draw a sample of that
plant or crop showing the good mutation or trait. (You may label the parts of a
crop or plant or write a brief explanation of the use of that gene in that plant).
Rubric
• Standards Rubric
• Appropriateness of Topic (Down Syndrome Awareness) 10 points
• Accuracy of Details and Information (taken from real scenario) 5 points
• Techniques (persuasiveness/humor in words/English or vernacular) 5 points
TOTAL - 20 points

Standards Rubric
Drawing Quality 10 points
Labels 5 points
Required Information (Title, Short Explanation) 5 points
Total: 20 points

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