"Mapping The Nephron" Cellular Templates: Gina Bartoni Lana Daniel Shin
"Mapping The Nephron" Cellular Templates: Gina Bartoni Lana Daniel Shin
"Mapping The Nephron" Cellular Templates: Gina Bartoni Lana Daniel Shin
the Nephron”
Cellular Templates
9/26/19
Daniel Shin
PCT
Lumen urine Interstitium blood
SGLTZ basolateral
Normal Physiology:
apical Nat
3Nat
CT
which 4 Htsecretor's Base
PTH
inhibits Natypoy3cotranstransport 94043excreta's PTIstraight
Proximal Tubule +
diuretic
Diuretic(s) with activity at this site: i
i e y
Haz Ht f nitz
d
basolateralNAHH
Htt
cos symporter t apical
Natankporteractivity
9 1
urinary NatlHaz
in Acetazola
water
follows solutes opp cannotbe
q delivery of solutes to macula densa Mannitolglycerin reabsorded
9 TG feedback 9 afferent arterior filteredfreely
resistance RBF Gfr abodyvolume
Hyperchlonemic metabolicacidosis big osmotic
apical
Normal Physiology:
basolateral
Resorbs Nat Kt CT
t
cellularresorption t
Indirectly la para 1
of
Mg2t t cart via lumen potential
co 2 kt
Kt backleak
trunk
generated by ftp.D kt t
Impermeable to H2O t
Cl
Makes urine less concentrated as
it ascends mgst
to 20 Natreabsorbed
9
Clinical Small Group #:
+ Diuretic Meck
Blockade
Diuretic(s) with activity at this site:
of NKC.cz
1
Furosemide
Torsemide
Trans
epithelialvoltage d Ethacrynic
Romy
acid
paracellularresorpbo's 4h20
ofmg2t Carty
afferentarteriole AGFR
alkalosis
Hypokalemia metabolic
of Kt Ht in collectingducts
9
men urine cos Interstitiumblood
Tubule e
2kt
EE
Reabsorbs Nat Cl to Get
Impermeable to H2O
EYE f Nat
t.PH
9Cat1Nut exchange a cartreabsorption MO Ht
S 10 Notreabsorbed t a
Ki
e
mga is absorbed by unknown mechanism Mg e
0mV
10mV
+ Diuretic Hotz
Chlorothiazide
Chlorthalidone
Diuretic(s) with activity at this site:
hlorthalidone
retainssignificant CA
activity
intracellular Natdrives basolateral
Naticaltexchanger
unknown
Tresorphin Mgk
4 absorption
of calcium to risk of osteoporotic fxs
Aldosterone T Htatpase activity I
go ite
THTsecretion 9 1
E
E Ift a
secreting Kt 2 Ht regulated by
aldosterone
Kt 2
t
Reasorb Kt F E
8
a
Hz Poy t NHytexcretion
Hoop Ht
ATP
It
11
Koz 203
Cortical Collecting
Duct + Diuretic A
u n l
Htsecretor hyperchloremic
metabolic
acidosis
Hyperkalemia
Spironolactone gynecomastomia
1 o ES c
Duct Aqua
pains
SecreteKt Kt
CF 3nat
Addaquaponins
Topical Kt conductance
O atp
Aldosterone
ENaC 1
I
Nat1kt pump 9 epithelia watchannel
i
µ
t m
ENac activity mRNAsyn from aldosterone
A
Ktsecretion a
ADH acts at Uz receptor insertion
of aguaporin H2O channels on apical
side
3 5 Nat reabsorbed secretion
Ktexcreted Cl absorbed drivels Ht
Clinical Small Group #:
9
ADH 9H2O reabsorption
Medullary Collecting
Duct + Diuretic
Diuretic(s) with activity at this site: discussed
later
4 sparing ANP
Amioride
Amiluride blocks ENac inhibiting triatnteremT
transepithelial potential
fitt secretion intercalatedcells i
q Spironalac
typerchloremic metabolic Acidosis Aldactone
Amiloride mimics Liddlesyndrome
4 Nat reabsorption
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