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Cell Junctions, Cell-Cell Adhesions

Tight junctions form a seal between epithelial cells to control the diffusion of molecules through the paracellular space and maintain cell polarity. Desmosomes anchor intermediate filaments of adjacent cells to provide strength to tissues. Gap junctions allow small molecules and electrical signals to pass between cells for coordination of functions.

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Rizky Nur Indah
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43 views

Cell Junctions, Cell-Cell Adhesions

Tight junctions form a seal between epithelial cells to control the diffusion of molecules through the paracellular space and maintain cell polarity. Desmosomes anchor intermediate filaments of adjacent cells to provide strength to tissues. Gap junctions allow small molecules and electrical signals to pass between cells for coordination of functions.

Uploaded by

Rizky Nur Indah
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PPTX, PDF, TXT or read online on Scribd
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 Cell Junctions, Cell-

Cell Adhesions
SEBAG BESAR SEL ORGANISME MULTISELULER

KERJASAMA DLM JARINGAN

ASOSIASI BERBAGAI KOMBINASI


DALAM UNIT FUNGSIONAL

ORGAN
SEL DLM JARINGAN

KONTAK DG MAKROMOLEKUL EKSTRASELULER


(MATRIKS)

SUSUNAN GEOMETRIS

MIGRASI DAN INTERAKSI

ADHESI DG SEL LAIN


CrossSection View of Intestine Wall
CELL JUNCTION tdpt pd

 KONTAK SEL DG SEL

 SEL DG MATRIKS
Cell-cell adhesion occurs through morphological structures and CAMs
Tight Junctions
Tight Junctions as barriers to solute diffusion
Electron-dense tracer is added in the apical (B) and
basal sides of the cells (C).
Tight Junctions Structures

Freeze-fracture EM
Models for Tight Junctions
Claudin and occludin
Transport accross tight junction
TIGHT JUNCTIONS
 Memblokir aliran cairan
antara sel-sel epithel.
 Membtk segel air yg rapat
dan mencegah material
melewati antar sel-sel.
 Material yg diserap hrs
dikontrol utk memblokir
substansi yg tdk diinginkan
masuk ke tbh.
 Kontrol dtg dr kenyataan bhw material hrs melalui
reseptor pd membran sel epithel.
Blok 3 Biologi Molekuler 12/05/2020 13
Role of tight junction

• Mechanical connection
• Barrier
• Inhibits:
entry of water-soluble molecules
lateral diffusion of membrane-components
• Ca2+ is required for the connections of occludins
• Permeability: inorganic small substances
amino acids
monosaccharides
Anchoring Junctions
Connecting cytoskeletons
Two Classes of anchoring junctions

a. Cell – Cell. b. Cell - Matrix


Focal Adhesion
Septate junction (invertebrata)

Cell 1

Cell 2

• on the apical part of the cells


• they form a continous belt (like z. adherens)
• promote to stick together the cells
• actin is anchored in this junction
Desmosomes
(menghub filamen intermediate satu sel dg sel lain)
Desmosomes (spt paku keling)
DESMOSOMES

 Desmosomes membtk links antara sel-sel, dan


memberikan koneksi antara filamen intermediate
pd sitoskeleton sel pd sel-sel yg berdekatan.
Struktur ini memberikan kekuatan pd jaringan
Blok 3 Biologi Molekuler 12/05/2020 24
Hemidesmosome : Menghubungkan permukaan basal sel epithel dg
lamina basalis
Gap Junctions
Size of molecules allowed to pass
Gap Junctions
Gap Junctions in EM
Each connexon is made of 6 subunits (connexin) and controls passage
of molecules with MW < 1000 Da
GAP JUNCTIONS
 Kebutuhan utk signaling
adl sebuah fungsi dr gap
junctions yg membtk pori-
pori yg yg menghub sel-
sel yg berdekatan

 Molekul dan sinyal elektrik pd satu sel dpt melewati


gap junctions ke sel-sel berdekatan. Proses ini
memungkinkan jar utk mengkoordinasikan thd stimuli.
Mis. gap junctions memungkinkan gerakan yg
terkoordinasi pd otot-otot yg menyebabkan kelahiran.

Blok 3 Biologi Molekuler 12/05/2020 30


Gap Junctions Functions

1. Rapid communication between neighboring


cells, e.g. cardiomyocytes need synchronized
actions

2. Communication beyond nerve system, e.g.


hepatocytes beyond sympathetic nerves need
to be informed to produce glucose from
glycogen

3. Embryogenesis, form specific tissue with


coupled group of cells
Gap junction
(1958, 1968)
• Bridges the 2-4 nm gap between the neighbour cells

• Hexagonal channel is formed (connexon)

• The wall of the channel is composed by 6 connexins


(4 helical components)

• The distribution of channels is tissue- or cell-specific


due to the difference of connexins

• Accross channels substances are transmitted


(max MW. 1000) by a regulated mechanism
Role of gap junction

• Transport of neurotransmitters, cAMP,


Ca 2+
• Signaling in early embryo
Summary of cell junctions
Summary of cell junctions
A summary of the various cell junctions found in a vertebrate
A summary of the various cell junctions found in a vertebrate
epithelial cell, classified according to their primary functions
epithelial cell, classified according to their primary functions

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