Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Mechanistic Toxicology Branch
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Christopher McPherson, Ph.D.
Staff Scientist
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Tel 984-287-4185
Fax 919-541-0870
[email protected]
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P.O. Box 12233
Mail Drop E1-07
Durham, NC 27709
Christopher McPherson, Ph.D. is a staff scientist in the NIEHS Division of Translational Toxicology (DTT) in the Mechanistic Toxicology Branch. He specializes in neurotoxicology and neurobiology. Christopher McPherson’s research examines in vitro and in vivo mechanisms of neurotoxicity throughout the lifespan, with a focus on characterizing inflammatory and molecular alterations due to contaminant exposure. His other interests include the use of high-throughput and high-content models to assess the neurotoxic potential of chemicals.
Christopher McPherson obtained his B.S. in Life Sciences from Arizona State University, followed by a Ph.D. in Toxicology from the University of North Carolina at Chapel Hill.
Selected Publications
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Kanungo J, Sorkin B, Krzykwa J, Mitchell C, Embry M, Spencer P, Harry G, Cannon J, Liu F, McPherson C, Gafner S, Westerink R. Screening tools to evaluate the neurotoxic potential of botanicals: building a strategy to assess safety.
Expert opinion on drug metabolism & toxicology.
2024 Jul;20(7):629-646.
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AbstractKanungo J, Sorkin B, Krzykwa J, Mitchell C, Embry M, Spencer P, Harry G, Cannon J, Liu F, McPherson C, Gafner S, Westerink R. Screening tools to evaluate the neurotoxic potential of botanicals: building a strategy to assess safety. Expert opinion on drug metabolism & toxicology. 2024 Jul
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McPherson C, Kelly-Rajan K, Lefebvre d'Hellencourt C, Harry G. High Content Imaging and Quantification of Microglia Phagocytosis In Vitro.
Current protocols.
2023 Jan;3(1):e638.
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AbstractMcPherson C, Kelly-Rajan K, Lefebvre d'Hellencourt C, Harry G. High Content Imaging and Quantification of Microglia Phagocytosis In Vitro. Current protocols. 2023 Jan
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Bowen C, Childers G, Perry C, Martin N, McPherson C, Lauten T, Santos J, Harry G. Mitochondrial-related effects of pentabromophenol, tetrabromobisphenol A, and triphenyl phosphate on murine BV-2 microglia cells.
Chemosphere.
2020 Sep;255:126919.
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AbstractBowen C, Childers G, Perry C, Martin N, McPherson C, Lauten T, Santos J, Harry G. Mitochondrial-related effects of pentabromophenol, tetrabromobisphenol A, and triphenyl phosphate on murine BV-2 microglia cells. Chemosphere. 2020 Sep
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Goulding D, Kraft A, Mouton P, McPherson C, Avdoshina V, Mocchetti I, Harry G. Age-Related Decrease in Tyrosine Hydroxylase Immunoreactivity in the Substantia Nigra and Region-Specific Changes in Microglia Morphology in HIV-1 Tg Rats.
Neurotoxicity research.
2019 Oct;36(3):563-582.
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AbstractGoulding D, Kraft A, Mouton P, McPherson C, Avdoshina V, Mocchetti I, Harry G. Age-Related Decrease in Tyrosine Hydroxylase Immunoreactivity in the Substantia Nigra and Region-Specific Changes in Microglia Morphology in HIV-1 Tg Rats. Neurotoxicity research. 2019 Oct
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McPherson C, Zhang G, Gilliam R, Brar S, Wilson R, Brix A, Picut C, Harry G. An Evaluation of Neurotoxicity Following Fluoride Exposure from Gestational Through Adult Ages in Long-Evans Hooded Rats.
Neurotoxicity research.
2018 Nov;34(4):781-798.
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AbstractMcPherson C, Zhang G, Gilliam R, Brar S, Wilson R, Brix A, Picut C, Harry G. An Evaluation of Neurotoxicity Following Fluoride Exposure from Gestational Through Adult Ages in Long-Evans Hooded Rats. Neurotoxicity research. 2018 Nov
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More Recent Publications from PubMed
